Analysis of Nontypeable Haemophilus influenzae Phase-Variable Genes During Experimental Human Nasopharyngeal Colonization
نویسندگان
چکیده
منابع مشابه
Analysis of nontypeable haemophilus influenzae phase-variable genes during experimental human nasopharyngeal colonization.
BACKGROUND Studies of nontypeable Haemophilus influenzae (NTHi) have demonstrated that a number of genes associated with infectivity have long repeat regions associated with phase variation in expression of the respective gene. The purpose of this study was to determine the genes that underwent phase variation during a 6-day period of experimental human nasopharyngeal colonization. METHODS St...
متن کاملIdentification of phase-variable genes that may contribute to nontypeable haemophilus influenzae nasopharyngeal colonization in humans contributes to our understanding of specific host-pathogen interactions.
Phase variation of surface components is an important mechanism by which bacteria can adapt rapidly to an ever-changing environment. Phase variation is a reversible switching on and off of genes, resulting in the expression of phenotypes that vary within a clonal population. The rate of phase variation is variable but may occur at a high frequency. There are several known molecular mechanisms r...
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Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic dise...
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Nontypeable Haemophilus influenzae is a common cause of respiratory tract disease and initiates infection by colonizing the nasopharynx. The H. influenzae Hap adhesin is an autotransporter protein that was discovered because it promotes intimate interaction with human epithelial cells. Hap contains an extracellular domain called Hap(s) that has adhesive and protease activity and an outer membra...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2013
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jit240